Publicaciones (últimos 10 años)


Chaverri C, Díaz C, Cicció JF. Leaf essential oil of Manekia naranjoana (Piperaceae) from Costa Rica and its cytotoxic activity. Nat Prod Commun. 2011, 6(1):145-8.


Soledad Mora, Victor Castro, Luis Poveda, Max Chavarría & Renato Murillo. Two new 3,4-seco-ent-kaurenes and other constituents from the Costa Rican endemic species Croton megistocarpus. Helv. Chim. Acta. (2011) 94, 1888-1892.


Schmidt CA, Murillo R, Heinzmann B, Laufer S, Wray V, Merfort I. Structural and conformational analysis of proanthocyanidins od Parapiptadenia rigida and their wound-healing properties. J. Nat. Prod. 2011, 74 (6), 1427-1436.


Schmidt CA, Murillo R, Bruhn T, Bringmann G, Goettert M, Heinzmann B, Brecht V, Laufer SA, Merfort I, Catechin derivatives from Papapiptadenia rigida with in vitro wound-healing properties. J. Nat. Prod. 2010, 73 (12) 2035-2041.


Quintão NL, da Silva GF, Antonialli CS, Rocha LW, Cechinel Filho V, Cicció JF. Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracetd from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice. Planta Med. 2010, 76(13):1411-8. 



Daum M, Schnell HJ, Herrmann S, Günther A, Murillo R, Müller R, Bisel P, Müller M, Bechthold A. Functions of genes and enzymes in phenalinolactone biosynthesis. Chembiochem. 2010, 11(10):1383-91.



Lamoureux, G.;, Agüero, C. A comparison of several modern alkylating agents.  ARKIVOC 2009, 251-264.


Ricciardi G, Cicció JF, Ocampo R, Lorenzo D, Ricciardi A, Bandoni A, Dellacassa E. Chemical variability of essentials oils of Lippia alba (Miller) N.E. Brown growing in Costa Rica and Argentina. Nat Prod Commun. 2009 Jun;4(6):853-8.



Lamoureux, G.; Perez, A.L.; Araya, M.; Agüero, C. Reactivity and Structure of Derivatives of 2-Hydroxy-1,4-Naphthoquinone (Lawsone). J. Phys. Org. Chem. 2008, 21, 1022-1028.


Omar A. Dupuy Loo, José A. Bonilla, Renato Murillo & Peter G. Taylor. Anticancer activities of two sesquiterpene lactones, millerenolide and thieleanin isolated from Viguiera sylvatica and Decachaeta thieleana. Fitoterapia2008,  79 (6): 428-32.


Díaz C, Quesada S, Brenes O, Aguilar G, Cicció JF. Chemical composition of Schinus molle essential oil and its cytotoxic activity on tumour cell lines. Nat Prod Res. 2008, 22(17):1521-34.


 Omar A. Dupuy L., Renato Murillo & José A. Bonilla. Actividad supresora del millerólido sobre células mononucleares de sangre periférica humana. Rev. Med. Chile2008, 136; 64-72.


Steffen Wagner, Raul Arce, Renato Murillo, Lothar Terfloth,Johann Gasteiger and Irmgard Merfort. Neural Networks as Valuable Tools to Differentiate Between Sesquiterpene Lactones’ Inhibitory Activity on Serotonin Release and on NF-kB. J. Med. Chem. 2008, 51, 1324-1332.


Renato Murillo, Alexander Briceño, Asiloé j. Mora and Gerson E. Delgado. 6a-Cinnamoyloxyeudeman-15-oic acid. Acta Chrystallographica Section E2007, E63, o2951.


Perez, A. L.; Lamoureux, G.; Zhen-Wu, B.Y. Synthesis of 2-Hydroxy-3-Substituted Naphthoquinones Using the Heck Reaction.Tetrahedron Lett. 2007, 3995-3998. 


Perez, A. L.; Lamoureux, G.; Sánchez-Kopper A. Efficient Synthesis of Dunnione and Streptocarpone. Tetrahedron Lett. 2007, 3735-3738.


Perez, A.L.; Lamoureux, G. Sudoku Puzzles for First-Year Organic Chemistry Students. J. Chem. Educ. 2007, 84, 614.


López-Antón, N., Hermann, C., Murillo, R., Merfort, I., Wanner, G., Vollmar, A. And Dirsch, V. „Sesquiterpene lactones induce distinct forms of cell death that modulate human monocyte-derived macrophage responses“. Apoptosis, 2007, 12(1), 141-53.


Reeves R.D., Baker, A.J.M., and Romero R.M. The ultramafic flora of the Santa Elena peninsula, Costa Rica: A biogeochemical reconnaissance.J. Geochem. Explor. 2007, 93, 153–159.


Lindenmeyer, M., Hrenn, A., Kern, C., Castro, V., Murillo, R., Mueller, S., Schulte-Moenting, J., Siedle, B. and Merfort, I., Sesquiterpene Lactones as Inhibitors of IL-8 Expression in HeLa Cells. Bioorganic and Medicinal Chemistry, 2006, 14(8):2487-97.

Durr C, Schnell HJ, Luzhetsky A, Murillo R, Weber M, Welzel K, Vente A, Bechthold A. Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tu6071: analysis of the gene cluster and generation of derivatives. Chemistry & Biology. 2006, 13,  365-77.


Bok JW, Hoffmeister D, Maggio-Hall LA, Murillo R, Glasner JD, Keller NP. Genomic mining for Aspergillus natural products. Chemistry & Biology, 2006, 13, 1-7.


Vitelvina Nuñez, Víctor Castro, Renato Murillo, Irmgard Merfort and Bruno Lomonte. Inhibitors effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothhrops snake venoms: isolation of 4-nerolidylcatechol as active principle. Phytochemistry, 2005, 66(9):1017-25.

Abebe Endale, Victor Wray, Renato Murillo, Peter C. Schmidt, Irmgard Merfort. Hopane-Type saponins from the seeds of Glinus lotoidesJ. Nat. Prod. 2005; 68(3); 443-446.

Kos, O., Castro, V., Murillo, R., Poveda, L. and Merfort. I. Ent-Kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosaPhytochemistry, 2005, 67, 62-69.


Grassl GA, Fessele S, Merfort I, Lindenmeyer MT, Castro V, Murillo R, Nelson PJ, Autenrieth IB. Sesquiterpene lactones inhibit Yersinia invasin protein-induced IL-8 and MCP-1 production in epithelial cells”. Int. J. Med, Microbiol. 2005, 295(8):531-8.

Perez, A. L.; Lamoureux, G.; Herrera, A. Synthesis of Iodinated Naphthoquinones Using Morpholine-Iodine Complex. Synthetic Comm. 2004, 34, 3389-3397.


Stefan Mueller, Renato Murillo, Victor Castro, Volker Brecht and irmgard Merfort., Sesquiterpene Lactones from Montanoa hibiscifolia that inhibit the transcription factor NF-kappaB.  J. Nat. Prod. 2004, 67 (4), 622-630.

C. Fuentes, V. Castro, J. Jakupovic and R. Murillo. Diterpenos y otros constituyentes de Croton hirtus (Euphorbiaceae).  Revista de Biología Tropical, 2004, 52 (1) 269-285.

Bettina Siedle, Alfonso J. García Piñeres, Renato Murillo, Jürgen Sculte-Möting, Víctor Castro, Peter Rüngeler, Christoph Klaas, Fernando B. da Costa, Wanda Kisiel, Irmgard Merfort., Quantitative Structure-Activity Relationship of Sesquiterne Lactones as Inhibitors of the Transkription Factor NF-kB. J. Med. Chem. 2004, 47 (24), 6042-6054.

Tamayo, G., Romero, R.M., Rosales, K., and Vargas, L.D. Medicinal plants popularly used for gastrointestinal disorders in Costa Rican Central Valley. J. Trop. Med. Plants. 2004 5(1),43-53.


Murch, S.J., Liu, C., Romero, R.M., and Saxena, P.K. Establishment of in vitrode novo regeneration and bioreactor production of Crescentia cujete L. Plant Cell, Tissue and Organ Culture. 2004 78(1), 63-68.


Mueller, S., Tirapelli, C. R., de Oliveira, A., Murillo, R., Castro, V. and Merfort, I., „Studies of ent-kaurane diterpenes from Oyedaea verbesinoides for their inhibitory activity on vascular smooth muscle contraction“, Phytochemistry, 2003, 63, 391-396.

B. Siedle, R. Murillo, O. Hucke, A. Labahn and I. Merfort, “Structure Activity Relationship of Cinnamic Acid Derivatives as Inhibitors of Human Neutrophil Elastase Revealed by Ligand Docking Calculations”. Pharmazie2003, 58 (5), 337-339.

Siedle, B., Gustavsson, L., Johansson, S., Murillo, R., Castro, V., Bohlin, L., Merfort, I.: The Effect of Sesquiterpene Lactones on the Release of Human Neutrophil Elastase; Biochemical Pharmacology, 2003, 65, 897-903.

B.Siedle, S.Cisielski, R.Murillo, B.Löser, V. Castro, C.A.Klaas, O.Hucke, A.Labahn, M.F.Melzig, I.Merfort, „Sesquiterpene Lactones as Inhibitors of Human Neutrophil Elastase“, Bioorganic & Medicinal Chemistry, 2002, 10, 2855-2861.